Pharmaceutical empty Capsule

Pharmaceutical empty capsules are pre-formed, two-piece shells designed to encapsulate powdered, granulated, semi-solid, or liquid drug formulations. They are widely used in oral solid dosage manufacturing due to their precision dosing, ease of use, and compatibility with a broad range of active pharmaceutical ingredients (APIs).
Available in gelatin (animal-derived) or vegetarian (HPMC, pullulan) options, these capsules meet diverse regulatory, cultural, and consumer preferences while ensuring stability, bioavailability, and patient compliance.

Types of Pharmaceutical Empty Capsules
1. Gelatin Capsules

• Source: Derived from bovine (BSE/TSE-free) or porcine collagen.
• Advantages:
• Excellent film-forming & rapid dissolution.
• Wide acceptance in pharma & nutraceuticals.

• Limitations: Not suitable for vegan, halal (if porcine), or moisture-sensitive formulations.

2. Vegetarian Capsules (HPMC/Pullulan)

• Source: Hydroxypropyl methylcellulose (HPMC) or pullulan (fermented starch).

Advantages:

• Animal-free, halal, kosher, and vegan-compliant.
• Low moisture content (<5%), ideal for hygroscopic APIs.

Limitations: Slightly slower dissolution than gelatin.

3. Specialized Capsules

• Enteric-coated: Delayed release (acid-resistant).
• Modified-release: Sustained or targeted delivery.
• Liquid-filled: For oils, suspensions, or volatile compounds.

Key Features & Benefits
1. Regulatory Compliance

• USP/EP/JP pharmacopeia standards for dissolution, disintegration, and heavy metals.
• EU & FDA-approved manufacturing facilities (GMP-certified).

2. Size Variants

• Standard sizes: 000, 00, 0, 1, 2, 3, 4, 5 (000 largest, 5 smallest).
• Custom sizes: For unique dosing needs.

3. Performance Attributes

• Low oxygen permeability: Protects sensitive APIs.
• Tight sealing: Prevents leakage in liquid-filled capsules.
• Printability: Branding or dosage identification.

4. Applications

• Prescription drugs: Antibiotics, probiotics, pain relievers.
• OTC supplements: Vitamins, herbal extracts.
• Clinical trials: Blinded placebo/drug studies.

Why Choose Pharmaceutical-Grade Empty Capsules?

• ✔ Precision dosing – Uniform fill weight & API distribution.
  ✔ Patient compliance – Easier to swallow than tablets.
  ✔ Formulation flexibility – Compatible with heat-sensitive APIs.
  ✔ Global acceptance – Meets USP, EP, JP, and ICH guidelines.

Conclusion
Pharmaceutical empty capsules are a critical component in drug delivery, offering versatility, compliance, and patient-centric benefits. Whether gelatin-based for cost efficiency or plant-based for ethical formulations, selecting the right capsule ensures stability, efficacy, and market readiness.

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